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Barley (Hordeum vulgare L.)



Interactions

Barley/Drug Interactions:
  • AnthelminticsAnthelmintics: A diet supplemented with barley reduced the bioavailability of triclabendazole in sheep, and theoretically may have a similar effect on other anthelmintics (60).
  • Antidiabetic agentsAntidiabetic agents: Barley contains more fermentable carbohydrate than other cereals, such as rice. Fermentation of undigested carbohydrate produces short chain fatty acids, some which may reduce hepatic glucose production and affect postprandial glycemia (47). Barley may result in lowered blood glucose concentrations, and when taken with hypoglycemic agents, theoretically may result in lower-than-expected blood glucose values (28; 29).
  • AntihypertensivesAntihypertensives: Based on a clinical trial in mildly hypercholesterolemic subjects, a combination of whole wheat, brown rice, and barley may decrease blood pressure. However, this effect may be due to the whole wheat and brown rice, as barley alone did not decrease blood pressure (61).
  • Antilipemic agentsAntilipemic agents: In clinical studies, barley use has been associated with decreased total cholesterol and low-density lipoprotein (LDL) concentrations, and may act additively with other cholesterol-lowering agents (62; 3; 4; 63; 8; 33).
  • SympathomimeticsSympathomimetics: Hordenine, an aminophenol in the root of germinating barley is a sympathomimetic, and combination use may theoretically result in additive effects. Human data are lacking in this area.

Barley/Herb/Supplement Interactions:
  • AntihelminticsAntihelmintics: A diet supplemented with barley reduced the bioavailability of triclabendazole in sheep, and theoretically may have a similar effect on other anthelmintics (60).
  • AntilipemicsAntilipemics: Barley use has been associated with decreased total cholesterol and low-density lipoprotein (LDL) concentrations, and may act additively with other cholesterol-lowering agents, such as niacin, garlic, guggul, or fish oil (62; 3; 4; 63; 8; 33).
  • HypoglycemicsHypoglycemics: Barley contains more fermentable carbohydrate than other cereals, such as rice. Fermentation of undigested carbohydrate produces short chain fatty acids, some which may reduce hepatic glucose production and affect postprandial glycemia (47). Barley may result in lowered blood glucose concentrations, and when taken with hypoglycemic agents, theoretically may result in lower-than-expected blood glucose values (28; 29).
  • HypotensivesHypotensives: Based on a clinical trial in mildly hypercholesterolemic subjects, a combination of whole wheat, brown rice, and barley may decrease blood pressure. However, this effect may be due to the whole wheat and brown rice, as barley alone did not decrease blood pressure (61).
  • SympathomimeticsSympathomimetics: Hordenine, an aminophenol in the root of germinating barley is a sympathomimetic. Theoretically, combination use may result in additive effects. Human data are lacking in this area.

Barley/Food Interactions:
  • Brown riceBrown rice: Based on a clinical trial in mildly hypercholesterolemic subjects, a combination of whole wheat, brown rice, and barley may decrease blood pressure. However, this effect may be due to the whole wheat and brown rice, as barley alone did not decrease blood pressure (61).
  • High carbohydrate foodsHigh carbohydrate foods: Based on a clinical study, a high dose of barley beta-glucan supplement may improve glucose control taken with high-carbohydrate foods, but not when added to a high-carbohydrate beverages (28).
  • Whole wheatWhole wheat: Based on a clinical trial in mildly hypercholesterolemic subjects, a combination of whole wheat, brown rice, and barley may decrease blood pressure. However, this effect may be due to the whole wheat and brown rice, as barley alone did not decrease blood pressure (61).

Barley/Lab Interactions:
  • Blood glucoseBlood glucose: Barley contains more fermentable carbohydrate than other cereals, such as rice. Fermentation of undigested carbohydrate produces short chain fatty acids, some of which may reduce hepatic glucose production and affect postprandial glycemia (47).
  • Insulin levelsInsulin levels: Based on two clinical trials, barley may decrease insulinemic response (28; 29).
  • Lipid panelLipid panel: Barley use has been associated with decreased total cholesterol and low-density lipoprotein (LDL) concentrations (62; 3; 4; 63).
  • Urine drug screensUrine drug screens: Hordenine, a constituent of barley, may yield false positive results with ELISA and TLC assays for various opiate drugs (64).

Copyright © 2011 Natural Standard (www.naturalstandard.com)


The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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